SINNAIS

represents a completely new approach to the delivery of therapeutics for a variety of difficult-to-treat disease models. It is the world’s first implantable pump capable of delivering metronomically controlled micro-doses of a drug and incorporating Josh Shachar’s proprietary biosensor technology to provide a physician with real-time biometric feedback on the effectiveness of the treatment.  Initially designed for treating brain-based CNS where existing delivery has low impact and high risk, the technology has many additional broad-based applications.

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DESCRIPTION

  • Implantable SMART Pump for Metronomic Delivery of Therapeutics
  • Provides complete autonomy to patients undergoing treatment dramatically improving quality of life. 
  • Ability to deliver therapeutics micro-dose levels as low as 1ml/hr.
  • MRI safe and certified to 10,000ft to allow air travel
  • Optical Sensor provides real-time biometric feedback of data such as temperature, fluid analysis, and therapeutic concentration levels allowing physicians to adjust drug delivery to maintain maximum effective dose and maximum tolerable dose thresholds. 
  • Wireless control allows system diagnostics, therapy analysis, and drug delivery to be controlled remotely by the physician from anywhere in the world. 

TECHNICAL

SIANNAIS PUMP

  • Pump Body Material: Titanium
  • Length: 31.5mm
  • Weight (empty): 90g
  • Reservoir Capacity: 6.9ml
  • Displacement Volume: 56.5ml
  • Diameter (including Catheter Access Port): 83mm
  • Implantable Lifespan: 6 months

OPTICAL SENSOR

  • Length: 31.5mm
  • Thickness: 5.7mm
  • Intraventricular Catheter Diameter x Length: 4.2mm x 70mm
  • Burr Hole Diameter 5mm
  • SOS Longevity 6 months
  • Exterior Shell Material:  Titanium
  • Skull Shell MAterial: Silicone
  • Catheter Fluid Lumen:
  • Optical Lens: Silica Glass
  • Return Lens: Silica Glass
  • CSF Sensing Chamber: Titanium

APPLICATIONS

SINNAIS provides an implantable drug delivery system capable of delivering metronomically controlled microdoses of a therapeutic to a patient while providing the physician remote real-time biofeedback treatment information and complete system and delivery control for a variety of health issues including:

  • Leptomeningeal Carcinomatosis
  • Glioblastoma Multiforme
  • Breast Cancer
  • Ovarian Cancer
  • Alzheimer’s
  • Parkinson’s
  • Dementia
  • Epilepsy
  • Pain Management
  • Diabetes
  • Organ Rejection Therapy

MEDIA