PATENTS
Method And Apparatus For Piezoelectric Layer-Wise Pump And Valve For Use In Local Administration Of Biological Response Modifiers And Therapeutic Agents
Patent Number: US 2004/0078027 AI
Date Filed: April 22, 2004
Country Filed In: USA
Product Application: SINNAIS Implantable Pump
Description:
A method and apparatus for local infusion of a variety of biological response modifiers (BRMs) and chemotherapeutic agents including tumor necrosis factors (TNF) are described. In one embodiment, the device contains a synthetic pouch compartmentalized into three or more chambers, and an electronic apparatus controlling and modulating the delivery of the agents to the site of the tumor, so as to achieve the desired regimen in support of the elimination of a tumor burden. In one embodiment, an electronic system provides tailored and controlled regulation of the administration of such agents, using sensors to monitor the progress of the treatment. Desired dosing and scheduling of antitumor agents in a local setting are provided. In one embodiment, active control and regulation of the administration of medicating agents are attached to a synthetic pouch and with the aid of a piezoelectric valve and pump actuating mechanism. The apparatus provides the desired dose, duration, and timing of dose delivery. In one embodiment, reporting the events in the tumor site via an RF link to the external control box is provided.
Field of Use: The SINNAIS Implantable Pump is the culmination of over a decade and a half of research and development for an implantable drug delivery pump incorporating Josh Shachar's biosensor technology to provide a step forward in providing patients with a more effective treatment protocol for pharma-based regimens where current systemic drug delivery is not as effective. The SINNAIS system provides metronomically controlled drug delivery at micro-dose levels with SMART biosensor feedback that provides a physician real-time data on a variety of treatment and patient vital metrics to allow for rapid response and modification of treatment from a remote location.