PATENTS
Metronomic Convection Enhanced Delivery Of Intrathecal Chemotherapy Using An Implanted Magnetic Breather Pump (MBP) For Leptomeningeal Carcinomatosis
Patent Number: 12/581 756
Date Filed: October 19, 2009
Country Filed In: USA
Product Application: SINNAIS Implantable Pump
Description:
A magnetically controlled pump is implanted into the cerebrospinal fluid of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double-walled lumen, an intratumoral catheter which will be implanted. Spinal fluid drawn from the patient is analyzed. Medication is delivered on a continuous metronomic basis into the CSF via an internalized pump. CSF is removed and analyzed for VEGF and other cytokines via spectrophotometer analysis or a lab on a chip. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.
Field of Use: The SINNAIS Implantable Pump is the culmination of over a decade and a half of research and development for an implantable drug delivery pump incorporating Josh Shachar's biosensor technology to provide a step forward in providing patients with a more effective treatment protocol for pharma-based regimens where current systemic drug delivery is not as effective. The SINNAIS system provides metronomically controlled drug delivery at micro-dose levels with SMART biosensor feedback that provides a physician real-time data on a variety of treatment and patient vital metrics to allow for rapid response and modification of treatment from a remote location.