PATENTS

Apparatus And Method For Overcoming Minimal Mass Sensitivity Limitations In A Shear Horizontal Surface Acoustic Wave Biosensor
Patent Number: US 2021/0181192 Al
Date Filed: June 17, 2021
Country Filed In: USA
Product Application: SAW Biosensor

Description:

The invention includes a method of assaying an analyte in a sample in a portable, handheld microfluidic reader. The method includes the steps of inserting the sample in the reader; capturing the analyte with a first antibody having a DNA tag attached thereto; capturing the analyte in the sample with a second antibody attached to a surface or having a magnetic nanoparticle (MNP) attached thereto; where a sandwich including the magnetic nanoparticle, first and second antibodies, the analyte and the DNA tag is formed; replicating the DNA tag using isothermal amplifi­cation to a predetermined amount of DNA tags detectable by a detector sufficient to overcome the minimal mass sensi­tivity limitations of the detector; and measuring the amount of replicated DNA tags using the detector. The invention also includes an apparatus or handheld portable field micro­fluidic reader in which the method is performed.
Field of Use: The SAW Biosensor is part of Josh Shachar's exploration into developing next-generation biosensors that are capable of detecting specific biomarkers within a sample at clinically relevant levels in a simple portable point-of-care-device that can provide physicians and healthcare workers rapid and affordable pathogen detection without the need for a dedicated lab and specialized technicians and all the associated cost therein. The SAW Biosensor technology represented a major leap forward in being able to lower the limits-of-detection and the time-to-detection of a biomarker by utilizing the generation of a Surface Acoustic Wave across a sensor-surface where targeted antigens had been captured from a sample of interest.

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