PATENTS
Method For Delivering Gene And Cell Therapy To A Tumor Or Targeted Site Using An Implanted Metronomic Biofeedback Pump
Patent Number: US 2012/0245565 Al
Date Filed: September 27, 2012
Country Filed In: USA
Product Application: SINNAIS Implantable Pump
Description:
A method for utilizing a controlled pump implanted into a patient connected to a multi-lumen catheter allowing delivery to and sampling from the brain or other organ for treatment of cancer. The pump delivers a plurality of medicating agents, including viral and non-viral vectors for gene therapy and cell therapy at a controlled rate, corresponding to the specific needs of the patient. A catheter is implanted in or adjacent to the tumoral region. Fluid drawn from the tumor region to the pump via the multi-lumen catheter is analyzed within the pump by various biofeedback sensors. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller. The method allows localized delivery of gene and cell therapy to a solid tumor or tumoral region, or to any other treatment area of interest within the patient.
Field of Use: The SINNAIS Implantable Pump is the culmination of over a decade and a half of research and development for an implantable drug delivery pump incorporating Josh Shachar's biosensor technology to provide a step forward in providing patients with a more effective treatment protocol for pharma-based regimens where current systemic drug delivery is not as effective. The SINNAIS system provides metronomically controlled drug delivery at micro-dose levels with SMART biosensor feedback that provides a physician real-time data on a variety of treatment and patient vital metrics to allow for rapid response and modification of treatment from a remote location.