Surface Acoustic Wave Biosensor Employing An Analog Front End And DNA Encoded Libraries To Improve Limit Of Detection (LOD) With Exemplary Apparatus Of The Same

Surface Acoustic Wave Biosensor Employing An Analog Front End And DNA Encoded Libraries To Improve Limit Of Detection (LOD) With Exemplary Apparatus Of The Same

Patent Number: US 2019/0170631 Al

Date Filed: June 6, 2019

Country Filed In: USA

Product Application: SAW Biosensor

A surface acoustic wave (SAW) performs a rapid, label-free detection of biological species. Biosensing and detection of multiple analytes multiplexed by an array of sensing lanes are configured to enable bio-amplification using engineered DNA encoded libraries as the probe through a phage display procedure to enhance specificity, capture statistics for the detection, screening and analyzing of the analyte in vitro. A biochemical formulation minimizes the limit of detection (LOD) at a threshold magnitude on the order of a femto­molar concentration. Additional enhancement of the appa­ratus is achieved by the use of an analog front end to amplify biochemical events.

Field of Use: The SAW Biosensor is part of Josh Shachar's exploration into developing next-generation biosensors that are capable of detecting specific biomarkers within a sample at clinically relevant levels in a simple portable point-of-care-device that can provide physicians and healthcare workers rapid and affordable pathogen detection without the need for a dedicated lab and specialized technicians and all the associated cost therein. The SAW Biosensor technology represented a major leap forward in being able to lower the limits-of-detection and the time-to-detection of a biomarker by utilizing the generation of a Surface Acoustic Wave across a sensor-surface where targeted antigens had been captured from a sample of interest.